Longevity research shows that a calorie-restricted diet without malnutrition reduces the incidence of age-related conditions. In fact, a clinical trial shows that Calorie Restriction (CR) affects many processes that regulate the rate of aging. Research supports the effects of intermittent fasting and its ability to put our body into ketosis, a state where the body burns fat for energy. CalerieHealth® supplements support longevity and healthy weight management with ingredients that mimic CR and exercise by boosting NAD+ levels and activating Sirtuins.*
Life Span
Take two (2) capsules per day with water before breakfast or between meals on an empty stomach.
Fisetin: Sirtuin Activating Compound
Fisetin is a naturally-occurring flavonoid with numerous health-promoting benefits. As a sirtuin-activating compound, Fisetin works synergistically with NAD precursors to fuel and accelerate longevity genes. Fisetin is also a powerful senolytic agent that supports NAD efficiency and may extend the healthspan. Fisetin is neuroprotective, fights inflammation, and supports brain function.*
β-NMN: High Bioavailability
NMN (Nicotinamide Mononucleotide) is a derivative of vitamin B3 that your body converts into Nicotinamide Adenine Dinucleotide (NAD+). NAD+ is found in all living cells and is necessary for metabolism to convert the food we eat into cellular energy. Poor aging and a number of related ailments are linked to low levels of NAD+. NMN may promote optimal aging, energy, and cognition by supporting healthy NAD+.*
Trans-Resveratrol: Sirtuin Activator
Resveratrol is an anti-aging powerhouse, a compound that repairs and renews the body on a cellular level. A mechanism for direct sirtuin activation, Resveratrol works synergistically with NAD precursors to fuel and accelerate longevity genes. A powerful therapeutic that mimics the longevity benefits of a calorie-restricted diet even when calories are not restricted. CalerieLife™ Resveratrol may be supplemented with NAD precursors such as CalerieLife™ NMN or taken as a single stand-alone ingredient. Experience CalerieLife™ today.*
BY: CALERIEHEALTH™ NUTRITIONALIST
Epigenetics is derived from a Greek word meaning Over & Above the Genome
It is known that aging is characterized by a decline in the function of body systems, tissues, and organs. There is evidence that shows the association between epigenetic changes and aging decline. The reason researchers are investigating epigenetics is that it can be reversed and that there are ways in the pathways to prevent age related decline and disease.
What is Epigenetics?
Epigenetics is a field of science that is evolving to study the changes caused by activating and deactivating genes. Epigenetic changes can actually be reversed without modifying the DNA structure and do not affect the sequence of DNA strands.
Epigenetics helps to explain why aging is different for 2 genetically identical people or animals. For example, identical twins age differently although they have the same genetic makeup. Another example is queen bees and worker bees.
What is the human genome?
The human genome is a complete group of DNA (deoxyribonucleic acid) in humans with all of its base pairs. The chromosomes in the genome hold the genetic information.
The epigenome is a collection of chemical components that dictate to the genome as to what it is to do. The epigenome is important because it is in control of the DNA functions. Changes made by epigenome can be impulsive or determined by effects from external or internal influences.
What can one do to improve their epigenetic pathway to live longer?
It has been stated that some of the most effective regimens to increase life span is partially through the epigenetic pathways (Pal S, Tyler JK, 2016).
It has been shown that the diet can actually cause variable changes of stored epigenetic information. In queen bees it has been shown that dietary changes can cause a unique difference in physical appearance, changes in reproduction and their life span even though they have identical DNA (Kucharski R et al, 2008).
One of the best ways to extend life span is by calorie restriction, which has been shown to have amazing effects on various organisms (Pal S, Tyler JK, 2016).
There is science in different species that shows that a diet high in simple sugar shortens the lifespan of particular compounds (Sen P et al, 2016).
Laboratory research shows that available nutrients are essential to determine lifespan (Bordone L Guarente L, 2005). The nutrients are described as amino acids, carbohydrates, growth factors and metabolites. They are detected by various proteins, which also includes glucose sensors.
These nutrients relay signals to the cell’s nucleus to make epigenetic changes to lifespan. The other mission of the nutrients is to modify the epigenome to effect lifespan and health span (time of life a person is in good health). Other factors of influence are exercise, hormones, circadian cycles (Sen P et al, 2016).
There have been plant based compounds that have been observed to have favorable effects. Those that are included are anthocyanidins found in blueberries and some other dark pigmented fruit, fisetin, flavones, stilbenes and chalcones (Pal S, Tyler JK, 2016). Resveratrol is considered one of the best nutrients since it has demonstrated to promote physiological and gene expression changes, which are comparable to those effects stimulated by a calorie restricted diet. Resveratrol has shown in animal research to improve health and survival when animals were placed on a high calorie diet (Sen P et al, 2016).
As with any new dietary regimen or consumption of supplements, if you have a health condition and or take medication it is best to check with your health care practitioner prior to starting something new.
In summary, aging is characterized by a decline in the operation of bodily functions. Evidence shows that there is an association between epigenetic changes and aging decline. Dietary measurements and nutrients can make a difference in epigenetic pathways, which has been observed in laboratory and animal research.
BY: CALERIEHEALTH™ NUTRITIONALIST
Resveratrol, niacin and nicotinamide mononucleotide (NMN) are key performers in helping to activate sirtuins to promote a longer lifespan. The research community has been quite intrigued to find and study these types of sirtuin activators because of their function. If the sirtuins can be activated humans have the opportunity to extend their lifespan.
The 7 Sirtuins
There are 7 sirtuins located in the body, which are made up of protein and are known to regulate cell activity and are critical to longevity (Grabowska W et al, 2017).
Sirtuins have been nicknamed “the magnificent seven” and have also been labelled “the master switches of metabolism” (Pizzorno L, 2018). If they do not function properly, cells age faster and there is increased risk for health problems. Also, sirtuins will perform when there is an overabundance of free radicals and extinguish them since their attack causes DNA damage in cells.
How are the sirtuins activated in the body?
One objective is to identify substances that boost NAD+ since it is required for sirtuins to function. Certain foods activate sirtuins in the body, but also it has been shown that calorie restriction and exercise activate them also, which helps to increase longevity (Pallauf K et al, 2013; Corbi B et al, 2012).
The 3 key performers resveratrol, Niacin, and NMN activate sirtuins, mainly SIRT1 (Kane AE, Sinclair DA, 2018).
Resveratrol (3,5,4′-trihydroxystilbene) has been studied the most and has shown great success as a nutritional SIRT1 activator. It is a bioactive from red wine and has been positioned to have cardiovascular protective effects. It has been studied to show that it activates the sirtuin gene and has a similar mechanism of action as calorie restriction to improve longevity (Baur JA, Sinclair DA, 2006). In addition, resveratrol is involved in helping to control regulatory enzymes such as lipooxygenases, cyclooxygenases, aromatase, kinases and ribonucleotide reductase.
It has been shown for decades that there is a tight connection between NAD and sirtuins and controlled at different metabolic levels making it more complex in its understanding. It has been shown that levels of NAD are reduced with age, which lowers sirtuin activities (Imai S-I, Guarente L, 2016). This interrupts cellular mitochondria and nucleus communication.
Niacin (vitamin B3 or nicotinic acid)
Niacin is found in different foods such as lentils, whole wheat bread and pasta, peanuts, salmon, halibut, chicken and turkey breast.
It is a building block for nicotinamide adenine dinucleotide (NAD). It operates in the mitochondria, involved in essential biochemical reactions to help form NAD (Djadjo S, Bajaj T, 2020). It is necessary that humans continuously consume niacin on a daily basis from the diet and/or supplements essential for NAD and its other functions. Niacin has been shown to activate Sirt1 in the liver, which is involved in regulating cholesterol and keeps lipids at normal levels (Pizzorno L, 2018).
Nicotinamide mononucleotide (NMN)
NMN as a sirtuin activator
It is known that sirtuin activity is controlled by NAD pathways and nicotinamide phosphoribosyltransferase (NAMPT). The NAMPT produces nicotinamide mononucleotide (NMN), which is also a SIRT1 activator (Imai S-I, 2010). NMN is changes to NAD in the process.
One should check with their health care practitioner if they have a health condition and/or take medication prior to taking a new supplement.
In summary, resveratrol, niacin and nicotinamide mononucleotide (NMN) have the special ability to activate sirtuins, which helps to increase one’s lifespan. There is so much yet to learn, but there is an understanding that sirtuins and NAD are closely connected. All 3 of these nutrients have been shown to operate as sirtuin activators. Niacin and NMN help to produce NAD at the cellular level to bring about the activation of sirtuins.
This article is for educational purposes only and is not intended to diagnose, treat, cure or prevent any disease. It is not for advertising purposes.
BY: CALERIEHEALTH™ NUTRITIONALIST
What is Xenohormesis?
The prefix xeno means a foreign substance or stranger and hormesis is a protective way to respond when there is mild stress in the environment.
Xenohormesis is a biological theory that shows how plants that are stressed in the environment produce bioactive substances that increase resistance and a means to survive to the animals that ingest them (Hooper PL et al, 2010). Some of the stresses to plants include dehydration, starvation, predator invasion, intense weather changes and plant cell damage (Howitz KT, Sinclair DA, 2008).
Process:
Plants become stressed
They produce bioactives in response to the stress
Animals consume the bioactives
Results: health benefits and increased longevity
A special group of nutrients called polyphenols are produced when plants are moderately stressed. This causes an activation of sirtuin enzymes that have been shown to prolong the lifespan of animals. This benefit copies the same effect that calorie restriction has on the body (Baur JA et al, 2008). It is possible that sirtuin enzymes role is to respond to plant stress molecules as a gauge that there is an approaching problem in the environment.
When the xenohormetic substances are consumed, it promotes the animal’s longevity and health. It does this by activating the cell’s stress response within the animals. Therefore, various nutrients have been studied to help improve longevity by having this mechanism of action (Hooper PL et al, 2010).
Some of these xenohormesis compounds are completely nontoxic compounds available in food such as resveratrol found in wine and quercetin available in tea, apples, and onions (Baur JA, Sinclair DA, 2006). Others include curcumin, black chokeberry, black current, dandelion and grapes (Hooper PL et al, 2010).
These polyphenols are an umbrella group of plant secondary metabolites that include various chemical classes. They consist of flavones, catechins, isoflavones, chalcones, stilbenes and anthocyanidins. Most of these bioactives are manufactured by the plants in response to stress (Baur JA, Sinclair DA, 2006).
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Resveratrol acts in the same way metabolically as restricting calories from the diet activating sirtuin (SIRT2) enzymes. It has been shown that resveratrol helped to stabilize DNA and increase lifespan by 70% in a yeast strain (Chung S et al, 2010).
This observation essentially formed the foundations of the xenohormesis hypothesis, sparking interest in phytochemically activated enzyme/receptor pathways and their origin.
Resveratrol stimulates over 24 enzymes and receptors in the body and in animal and some human studies it demonstrates that it protects the heart and arteries cells against damaging changes and promotes healthy blood sugar levels (Baur JA, Sinclair DA, 2006).
Resveratrol has been shown to activate AMPK which is believed to be one of the major mechanisms of action of how it brings health to the body (Hooper PL et al, 2010). Also, resveratrol has demonstrated to activate Sirt1, which helps to increase lifespan (Duan W, 2013).
AMP-activated protein kinase (AMPK) is known as the “metabolic master switch.” Its activity has an effect in reducing the accumulation of fat within fat cells. Therefore, resveratrol provides support to blood sugar and weight management (Viollet B, Andreelli F, 2011).
In conclusion, xenohormesis is a theory that shows how plants that are stressed in the environment produce bioactive substances that increase resistance. When animals eat these substances they improve health and longevity. Some of these substances are polyphenols found in food such as resveratrol and quercetin.
This article is for educational purposes only and is not intended to diagnose, treat, cure or prevent any disease. Individuals with health concerns or on medication should check with their health care practitioner before trying any new type of health approach.